MLB scores, schedule and odds: Wednesday, September 22, 2027
The MLB schedule for Wednesday, September 22, 2027 has 15 games.
First up: Cubs at Phillies at 12:00 AM ET on MLB.TV.
- Chicago Cubs at Philadelphia Phillies — Wed, Sep 22 12:00 AM ET · Citizens Bank Park, Philadelphia
- Cincinnati Reds at Baltimore Orioles — Wed, Sep 22 12:00 AM ET · Oriole Park at Camden Yards, Baltimore
- Detroit Tigers at Chicago White Sox — Wed, Sep 22 12:00 AM ET · Rate Field, Chicago
- Houston Astros at Athletics — Wed, Sep 22 12:00 AM ET · Sutter Health Park, Sacramento
- Kansas City Royals at Cleveland Guardians — Wed, Sep 22 12:00 AM ET · Progressive Field, Cleveland
- Los Angeles Dodgers at Colorado Rockies — Wed, Sep 22 12:00 AM ET · Coors Field, Denver
- Miami Marlins at Texas Rangers — Wed, Sep 22 12:00 AM ET · Globe Life Field, Arlington
- Milwaukee Brewers at St. Louis Cardinals — Wed, Sep 22 12:00 AM ET · Busch Stadium, St. Louis
- New York Yankees at Toronto Blue Jays — Wed, Sep 22 12:00 AM ET · Rogers Centre, Toronto
- Pittsburgh Pirates at New York Mets — Wed, Sep 22 12:00 AM ET · Citi Field, Queens
- San Diego Padres at Arizona Diamondbacks — Wed, Sep 22 12:00 AM ET · Chase Field, Phoenix
- Seattle Mariners at Los Angeles Angels — Wed, Sep 22 12:00 AM ET · Angel Stadium, Anaheim
- San Francisco Giants at Minnesota Twins — Wed, Sep 22 12:00 AM ET · Target Field, Minneapolis
- Tampa Bay Rays at Boston Red Sox — Wed, Sep 22 12:00 AM ET · Fenway Park, Boston
- Washington Nationals at Atlanta Braves — Wed, Sep 22 12:00 AM ET · Truist Park, Atlanta