MLB scores, schedule and odds: Wednesday, September 15, 2027

The MLB schedule for Wednesday, September 15, 2027 has 15 games.

First up: Angels at Astros at 12:00 AM ET on MLB.TV.

• Los Angeles Angels at Houston Astros — Wed, Sep 15 12:00 AM ET · Daikin Park, Houston
• Arizona Diamondbacks at San Francisco Giants — Wed, Sep 15 12:00 AM ET · Oracle Park, San Francisco
• Athletics at Tampa Bay Rays — Wed, Sep 15 12:00 AM ET · Tropicana Field, St. Petersburg
• Atlanta Braves at San Diego Padres — Wed, Sep 15 12:00 AM ET · Petco Park, San Diego
• Baltimore Orioles at Chicago Cubs — Wed, Sep 15 12:00 AM ET · Wrigley Field, Chicago
• Boston Red Sox at Milwaukee Brewers — Wed, Sep 15 12:00 AM ET · American Family Field, Milwaukee
• Chicago White Sox at New York Yankees — Wed, Sep 15 12:00 AM ET · Yankee Stadium, Bronx
• Cleveland Guardians at Kansas City Royals — Wed, Sep 15 12:00 AM ET · Kauffman Stadium, Kansas City
• Colorado Rockies at Miami Marlins — Wed, Sep 15 12:00 AM ET · loanDepot park, Miami
• Minnesota Twins at Detroit Tigers — Wed, Sep 15 12:00 AM ET · Comerica Park, Detroit
• New York Mets at Washington Nationals — Wed, Sep 15 12:00 AM ET · Nationals Park, Washington
• Philadelphia Phillies at Cincinnati Reds — Wed, Sep 15 12:00 AM ET · Great American Ball Park, Cincinnati
• St. Louis Cardinals at Pittsburgh Pirates — Wed, Sep 15 12:00 AM ET · PNC Park, Pittsburgh
• Texas Rangers at Seattle Mariners — Wed, Sep 15 12:00 AM ET · T-Mobile Park, Seattle
• Toronto Blue Jays at Los Angeles Dodgers — Wed, Sep 15 12:00 AM ET · Dodger Stadium, Los Angeles