MLB scores, schedule and odds: Wednesday, April 22, 2026

The MLB schedule for Wednesday, April 22, 2026 has 15 games.

• St. Louis Cardinals at Miami Marlins — STL 1, MIA 4 (Final) · loanDepot park, Miami
• Cincinnati Reds at Tampa Bay Rays — CIN 1, TB 6 (Final) · Tropicana Field, St. Petersburg
• Houston Astros at Cleveland Guardians — HOU 2, CLE 0 (Final) · Progressive Field, Cleveland
• Baltimore Orioles at Kansas City Royals — BAL 8, KC 6 (Final) · Kauffman Stadium, Kansas City
• Toronto Blue Jays at Los Angeles Angels — TOR 3, LAA 7 (Final) · Angel Stadium, Anaheim
• Athletics at Seattle Mariners — ATH 4, SEA 5 (Final) · T-Mobile Park, Seattle
• Milwaukee Brewers at Detroit Tigers — MIL 2, DET 5 (Final) · Comerica Park, Detroit
• Atlanta Braves at Washington Nationals — ATL 8, WSH 6 (Final) · Nationals Park, Washington
• New York Yankees at Boston Red Sox — NYY 4, BOS 1 (Final) · Fenway Park, Boston
• Minnesota Twins at New York Mets — MIN 2, NYM 3 (Final) · Citi Field, Queens
• Philadelphia Phillies at Chicago Cubs — PHI 2, CHC 7 (Final) · Wrigley Field, Chicago
• Pittsburgh Pirates at Texas Rangers — PIT 8, TEX 4 (Final) · Globe Life Field, Arlington
• San Diego Padres at Colorado Rockies — SD 3, COL 8 (Final) · Coors Field, Denver
• Chicago White Sox at Arizona Diamondbacks — CHW 7, ARI 11 (Final) · Chase Field, Phoenix
• Los Angeles Dodgers at San Francisco Giants — LAD 0, SF 3 (Final) · Oracle Park, San Francisco