MLB scores, schedule and odds: Tuesday, April 21, 2026

The MLB schedule for Tuesday, April 21, 2026 has 15 games.

• Houston Astros at Cleveland Guardians — HOU 5, CLE 8 (Final) · Progressive Field, Cleveland
• Cincinnati Reds at Tampa Bay Rays — CIN 12, TB 6 (Final) · Tropicana Field, St. Petersburg
• Milwaukee Brewers at Detroit Tigers — MIL 12, DET 4 (Final) · Comerica Park, Detroit
• St. Louis Cardinals at Miami Marlins — STL 5, MIA 3 (Final) · loanDepot park, Miami
• Atlanta Braves at Washington Nationals — ATL 4, WSH 11 (Final) · Nationals Park, Washington
• New York Yankees at Boston Red Sox — NYY 4, BOS 0 (Final) · Fenway Park, Boston
• Minnesota Twins at New York Mets — MIN 5, NYM 3 (Final) · Citi Field, Queens
• Baltimore Orioles at Kansas City Royals — BAL 5, KC 6 (Final) · Kauffman Stadium, Kansas City
• Philadelphia Phillies at Chicago Cubs — PHI 4, CHC 7 (Final) · Wrigley Field, Chicago
• Pittsburgh Pirates at Texas Rangers — PIT 1, TEX 5 (Final) · Globe Life Field, Arlington
• San Diego Padres at Colorado Rockies — SD 1, COL 0 (Final) · Coors Field, Denver
• Toronto Blue Jays at Los Angeles Angels — TOR 4, LAA 2 (Final) · Angel Stadium, Anaheim
• Athletics at Seattle Mariners — ATH 5, SEA 2 (Final) · T-Mobile Park, Seattle
• Chicago White Sox at Arizona Diamondbacks — CHW 11, ARI 5 (Final) · Chase Field, Phoenix
• Los Angeles Dodgers at San Francisco Giants — LAD 1, SF 3 (Final) · Oracle Park, San Francisco