MLB scores, schedule and odds: Monday, April 21, 2025

The MLB schedule for Monday, April 21, 2025 has 8 games.

• Chicago White Sox at Boston Red Sox — CHW 2, BOS 4 (Final) · Fenway Park, Boston
• New York Yankees at Cleveland Guardians — NYY 4, CLE 6 (Final) · Progressive Field, Cleveland
• Cincinnati Reds at Miami Marlins — CIN 3, MIA 6 (Final) · loanDepot park, Miami
• San Diego Padres at Detroit Tigers — SD 4, DET 6 (Final) · Comerica Park, Detroit
• Philadelphia Phillies at New York Mets — PHI 4, NYM 5 (Final) · Citi Field, Queens
• St. Louis Cardinals at Atlanta Braves — STL 6, ATL 7 (Final) · Truist Park, Atlanta
• Toronto Blue Jays at Houston Astros — TOR 0, HOU 7 (Final) · Daikin Park, Houston
• Milwaukee Brewers at San Francisco Giants — MIL 2, SF 5 (Final) · Oracle Park, San Francisco