MLB scores, schedule and odds: Friday, May 21, 2027

The MLB schedule for Friday, May 21, 2027 has 15 games.

First up: Angels at Phillies at 12:00 AM ET on MLB.TV.

• Los Angeles Angels at Philadelphia Phillies — Fri, May 21 12:00 AM ET · Citizens Bank Park, Philadelphia
• Atlanta Braves at Kansas City Royals — Fri, May 21 12:00 AM ET · Kauffman Stadium, Kansas City
• Baltimore Orioles at Cleveland Guardians — Fri, May 21 12:00 AM ET · Progressive Field, Cleveland
• Chicago White Sox at Pittsburgh Pirates — Fri, May 21 12:00 AM ET · PNC Park, Pittsburgh
• Colorado Rockies at Arizona Diamondbacks — Fri, May 21 12:00 AM ET · Chase Field, Phoenix
• Detroit Tigers at St. Louis Cardinals — Fri, May 21 12:00 AM ET · Busch Stadium, St. Louis
• Houston Astros at Athletics — Fri, May 21 12:00 AM ET · Sutter Health Park, Sacramento
• Milwaukee Brewers at Miami Marlins — Fri, May 21 12:00 AM ET · loanDepot park, Miami
• New York Mets at Minnesota Twins — Fri, May 21 12:00 AM ET · Target Field, Minneapolis
• San Diego Padres at Los Angeles Dodgers — Fri, May 21 12:00 AM ET · Dodger Stadium, Los Angeles
• San Francisco Giants at New York Yankees — Fri, May 21 12:00 AM ET · Yankee Stadium, Bronx
• Tampa Bay Rays at Seattle Mariners — Fri, May 21 12:00 AM ET · T-Mobile Park, Seattle
• Texas Rangers at Boston Red Sox — Fri, May 21 12:00 AM ET · Fenway Park, Boston
• Toronto Blue Jays at Cincinnati Reds — Fri, May 21 12:00 AM ET · Great American Ball Park, Cincinnati
• Washington Nationals at Chicago Cubs — Fri, May 21 12:00 AM ET · Wrigley Field, Chicago