MLB scores, schedule and odds: Wednesday, April 28, 2027

The MLB schedule for Wednesday, April 28, 2027 has 15 games.

First up: Angels at Astros at 12:00 AM ET on MLB.TV.

• Los Angeles Angels at Houston Astros — Wed, Apr 28 12:00 AM ET · Daikin Park, Houston
• Arizona Diamondbacks at Detroit Tigers — Wed, Apr 28 12:00 AM ET · Comerica Park, Detroit
• Athletics at Minnesota Twins — Wed, Apr 28 12:00 AM ET · Target Field, Minneapolis
• Atlanta Braves at St. Louis Cardinals — Wed, Apr 28 12:00 AM ET · Busch Stadium, St. Louis
• Boston Red Sox at Baltimore Orioles — Wed, Apr 28 12:00 AM ET · Oriole Park at Camden Yards, Baltimore
• Chicago White Sox at Los Angeles Dodgers — Wed, Apr 28 12:00 AM ET · Dodger Stadium, Los Angeles
• Colorado Rockies at Cleveland Guardians — Wed, Apr 28 12:00 AM ET · Progressive Field, Cleveland
• Miami Marlins at Cincinnati Reds — Wed, Apr 28 12:00 AM ET · Great American Ball Park, Cincinnati
• Milwaukee Brewers at Chicago Cubs — Wed, Apr 28 12:00 AM ET · Wrigley Field, Chicago
• New York Yankees at Kansas City Royals — Wed, Apr 28 12:00 AM ET · Kauffman Stadium, Kansas City
• Philadelphia Phillies at San Diego Padres — Wed, Apr 28 12:00 AM ET · Petco Park, San Diego
• Pittsburgh Pirates at Tampa Bay Rays — Wed, Apr 28 12:00 AM ET · Tropicana Field, St. Petersburg
• Seattle Mariners at San Francisco Giants — Wed, Apr 28 12:00 AM ET · Oracle Park, San Francisco
• Texas Rangers at Washington Nationals — Wed, Apr 28 12:00 AM ET · Nationals Park, Washington
• Toronto Blue Jays at New York Mets — Wed, Apr 28 12:00 AM ET · Citi Field, Queens