MLB scores, schedule and odds: Thursday, April 22, 2027

The MLB schedule for Thursday, April 22, 2027 has 9 games.

First up: Guardians at Blue Jays at 12:00 AM ET on MLB.TV.

• Cleveland Guardians at Toronto Blue Jays — Thu, Apr 22 12:00 AM ET · Rogers Centre, Toronto
• Detroit Tigers at Chicago White Sox — Thu, Apr 22 12:00 AM ET · Rate Field, Chicago
• Kansas City Royals at Baltimore Orioles — Thu, Apr 22 12:00 AM ET · Oriole Park at Camden Yards, Baltimore
• Los Angeles Dodgers at Philadelphia Phillies — Thu, Apr 22 12:00 AM ET · Citizens Bank Park, Philadelphia
• San Diego Padres at Colorado Rockies — Thu, Apr 22 12:00 AM ET · Coors Field, Denver
• Seattle Mariners at Athletics — Thu, Apr 22 12:00 AM ET · Sutter Health Park, Sacramento
• San Francisco Giants at Pittsburgh Pirates — Thu, Apr 22 12:00 AM ET · PNC Park, Pittsburgh
• Tampa Bay Rays at Boston Red Sox — Thu, Apr 22 12:00 AM ET · Fenway Park, Boston
• Washington Nationals at Atlanta Braves — Thu, Apr 22 12:00 AM ET · Truist Park, Atlanta