MLB scores, schedule and odds: Friday, May 22, 2026

The MLB schedule for Friday, May 22, 2026 has 15 games.

• Houston Astros at Chicago Cubs — HOU 4, CHC 2 (Final) · Wrigley Field, Chicago
• Cleveland Guardians at Philadelphia Phillies — CLE 1, PHI 0 (Final) · Citizens Bank Park, Philadelphia
• St. Louis Cardinals at Cincinnati Reds — STL 0, CIN 0 (Postponed) · Great American Ball Park, Cincinnati
• Tampa Bay Rays at New York Yankees — TB 4, NYY 2 (Final) · Yankee Stadium, Bronx
• Pittsburgh Pirates at Toronto Blue Jays — PIT 2, TOR 6 (Final) · Rogers Centre, Toronto
• Minnesota Twins at Boston Red Sox — MIN 8, BOS 6 (Final) · Fenway Park, Boston
• New York Mets at Miami Marlins — NYM 1, MIA 2 (Final) · loanDepot park, Miami
• Detroit Tigers at Baltimore Orioles — DET 4, BAL 7 (Final) · Oriole Park at Camden Yards, Baltimore
• Washington Nationals at Atlanta Braves — WSH 4, ATL 5 (Final/11) · Truist Park, Atlanta
• Los Angeles Dodgers at Milwaukee Brewers — LAD 1, MIL 5 (Final) · American Family Field, Milwaukee
• Seattle Mariners at Kansas City Royals — SEA 2, KC 0 (Final) · Kauffman Stadium, Kansas City
• Texas Rangers at Los Angeles Angels — TEX 6, LAA 9 (Final) · Angel Stadium, Anaheim
• Athletics at San Diego Padres — ATH 3, SD 7 (Final) · Petco Park, San Diego
• Colorado Rockies at Arizona Diamondbacks — COL 3, ARI 2 (Final) · Chase Field, Phoenix
• Chicago White Sox at San Francisco Giants — CHW 9, SF 4 (Final) · Oracle Park, San Francisco