MLB scores, schedule and odds: Wednesday, September 17, 2025

The MLB schedule for Wednesday, September 17, 2025 has 15 games.

• Chicago Cubs at Pittsburgh Pirates — CHC 8, PIT 4 (Final) · PNC Park, Pittsburgh
• Cincinnati Reds at St. Louis Cardinals — CIN 6, STL 2 (Final) · Busch Stadium, St. Louis
• Baltimore Orioles at Chicago White Sox — BAL 3, CHW 1 (Final) · Rate Field, Chicago
• San Francisco Giants at Arizona Diamondbacks — SF 5, ARI 1 (Final/11) · Chase Field, Phoenix
• Atlanta Braves at Washington Nationals — ATL 9, WSH 4 (Final) · Nationals Park, Washington
• Cleveland Guardians at Detroit Tigers — CLE 4, DET 0 (Final) · Comerica Park, Detroit
• Athletics at Boston Red Sox — ATH 4, BOS 5 (Final/10) · Fenway Park, Boston
• Toronto Blue Jays at Tampa Bay Rays — TOR 1, TB 2 (Final) · George M. Steinbrenner Field, Tampa
• San Diego Padres at New York Mets — SD 7, NYM 4 (Final) · Citi Field, Queens
• Los Angeles Angels at Milwaukee Brewers — LAA 2, MIL 9 (Final) · American Family Field, Milwaukee
• New York Yankees at Minnesota Twins — NYY 10, MIN 5 (Final) · Target Field, Minneapolis
• Seattle Mariners at Kansas City Royals — SEA 5, KC 7 (Final) · Kauffman Stadium, Kansas City
• Texas Rangers at Houston Astros — TEX 2, HOU 5 (Final) · Daikin Park, Houston
• Miami Marlins at Colorado Rockies — MIA 8, COL 4 (Final) · Coors Field, Denver
• Philadelphia Phillies at Los Angeles Dodgers — PHI 0, LAD 5 (Final) · Dodger Stadium, Los Angeles