MLB scores, schedule and odds: Wednesday, May 21, 2025

The MLB schedule for Wednesday, May 21, 2025 has 16 games.

• Cleveland Guardians at Minnesota Twins — CLE 5, MIN 6 (Final) · Target Field, Minneapolis
• Cincinnati Reds at Pittsburgh Pirates — CIN 1, PIT 3 (Final) · PNC Park, Pittsburgh
• Chicago Cubs at Miami Marlins — CHC 2, MIA 1 (Final) · loanDepot park, Miami
• Houston Astros at Tampa Bay Rays — HOU 4, TB 8 (Final) · George M. Steinbrenner Field, Tampa
• Baltimore Orioles at Milwaukee Brewers — BAL 8, MIL 4 (Final/11) · American Family Field, Milwaukee
• Detroit Tigers at St. Louis Cardinals — DET 5, STL 1 (Final) · Busch Stadium, St. Louis
• Seattle Mariners at Chicago White Sox — SEA 6, CHW 5 (Final) · Rate Field, Chicago
• Kansas City Royals at San Francisco Giants — KC 8, SF 4 (Final) · Oracle Park, San Francisco
• Cleveland Guardians at Minnesota Twins — CLE 5, MIN 1 (Final) · Target Field, Minneapolis
• Atlanta Braves at Washington Nationals — ATL 0, WSH 0 (Postponed) · Nationals Park, Washington
• New York Mets at Boston Red Sox — NYM 5, BOS 1 (Final) · Fenway Park, Boston
• Texas Rangers at New York Yankees — TEX 3, NYY 4 (Final) · Yankee Stadium, Bronx
• San Diego Padres at Toronto Blue Jays — SD 0, TOR 14 (Final) · Rogers Centre, Toronto
• Philadelphia Phillies at Colorado Rockies — PHI 9, COL 5 (Final) · Coors Field, Denver
• Los Angeles Angels at Athletics — LAA 10, ATH 5 (Final) · Sutter Health Park, Sacramento
• Arizona Diamondbacks at Los Angeles Dodgers — ARI 1, LAD 3 (Final) · Dodger Stadium, Los Angeles